Chitosan grafted into mesoporous silica nanoparticles as benznidazol carrier for Chagas diseases treatment

Citation:

Nhavene EPF, da Silva WM, Junior RRT, Gastelois PL, Venâncio T, Nascimento R, Baptista RJC, Machado CR, de Macedo WAA, de Sousa EMB. Chitosan grafted into mesoporous silica nanoparticles as benznidazol carrier for Chagas diseases treatment. Microporous and Mesoporous Materials [Internet]. 2018:-.

Abstract:

Abstract The use of chitosan functionalized silica for benznidazole delivery in the treatment of neglected disease such as Chagas disease is one of the forms not yet explored, but with great potential for this therapy, as little is known about nanoformulations for the treatment of Chagas disease. In this work, we used chitosan-succinate covalently attached to the surface pore of \MSNs\ to act as anchor for benznidazole as a delivery system. The samples were characterized structurally and chemically with multiple techniques. The applicability of functionalized \MSNs\ as platforms for benznidazole delivery into T. cruzi parasites was assessed. The results demonstrate that the proposed system is a potential promising nanoplatform for drug and gene delivery targeting neglected diseases such as Chagas disease.

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